The two 2,3- and 3,4-dihydroxy hydrazones 5b and 5d were the most effective radical scavengers in all studied systems. The antioxidant activity of the target compounds was elucidated in vitro against stable free radicals DPPH and ABTS as well as iron induced oxidative damage in model systems containing biologically relevant molecules lecithin and deoxyribose. 5b and 5d killed the total parasitic larvae (100% effectiveness) after 24 hours incubation period at 37 ☌ in both concentrations (50 and 100 μg ml-1). spiralis was studied in vitro thus indicating that all hydrazones were more active than the clinically used anthelmintic drugs albendazole and ivermectin. The anthelmintic activity on encapsulated T. With the aim of developing a class of compounds combining anthelmintic with antioxidant properties, a series of new benzimidazolyl-2-hydrazones 5a-l, bearing hydroxyl- and methoxy-groups, were synthesized. Meanwhile, some studies have showed that these parasites induce oxidative stress in the infected host. spiralis), are widespread around the world and lead to morbidity and mortality in the population.
Parasitic infections, caused mainly by the species Trichinella spiralis (T.
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